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Blood Assay Solutions
In vitro tests on fresh primary cells
Blood Assay Solutions tests your products on fresh whole blood. Unlike in vitro assays using isolated PBMC, whole blood assays are carried out in the presence of all normal blood components i.e. PBMC, autologous serum, red blood cells, platelets. In addition, there is no antibiotic, no animal serum, no trace of cryoprotectant interfering with your results.
We also develop customized assays based on the use of fresh whole blood to suit your needs for discovery and preclinical programs.
" Our predefined InBlood Assay™ tests allow you to quickly evaluate the bioactivity of your products on primary cells in whole blood."
What makes Blood Assay Solutions different ?
Thanks to a pre-negotiated access to fresh whole blood, Blood Assay Solutions carries out your tests quickly. These whole blood assays can be done on blood from several donors allowing you to extend the validity of your results to different individuals. For selected cytokine readouts, we use a FRET-based technique (HTRF®) which has several advantages over ELISA: homogenous i.e. no multiple incubation/washing steps, lower assay volume, better dynamic range and lower background.
Who uses these tests?
There are blood assays to support and to speed up the decision-making process, whether you are:
- A biotech or a pharmaceutical company developing biologics or small molecules (e.g. cytokine or cytokine receptor antagonists, JAK/STAT inhibitors, TLR & inflammasome modulators)
- A manufacturer of research products (reagents, cell culture plasticware)
- A company producing cosmetics
- A company developing food supplements e.g. probiotics
HTRF® is a proprietary technology and a registered trademark of Cisbio Bioassays
Applications
- Bioactivity testing
- Modulation of inflammation and immunotoxicity
- Cytokine storm and cytokine release syndrome
- Immunogenicity
- Cross-species reactivity and toxicology studies
- Vaccine development: adjuvant, specific immune response
- Pyrogen detection – Monocyte activation test
- Cell culture plasticware and reagents
- Allergenicity
You want to test your compounds in vitro on blood?
Contact us to discuss the design of your assay and to get a quote.
Resources about whole blood assays
Application note on whole blood assays
Download the application note written with Cisbio.
Assessment of neutrophil activity
A simple whole blood assay shown to be as informative as invasive experimental techniques.
New publication co-authored by Blood Assay Solutions
« Toll-Like Receptors: Ligands, Cell-Based Models, and Readouts for Receptor Action»